The dual-wavelength ps fiber lasers from AFS Jena supply ultra-short pulsed laser light to a nonlinear microscope developed by the Leibniz Institute of Photonic Technology (ipht) Jena.
Thanks to this cooperation, high quality and high speed microscopic multimodal non-linear imaging is possible by e.g. simultaneously probing the coherent anti-stokes raman spectroscopy (CARS) CH-vibrational-levels of lipids around 2850cm-1 and of protein around 2930 cm-1, the second harmonic generation (SHG) and the two-photon excited fluorescence (TPEF) signals.
Pictures1 & 2: by courtesy of ipht Jena
This brings microscopic multimodal non-linear imaging for medical applications a huge step forward, for example CARS spectroscopy and microscopy for brain cancer detection during surgery and other clinical applications such as the examination of human aorta sections, human perivascular tissue, animal tissue and many more.
Picture 3-6: by courtesy of ipht Jena
The design of the laser, microscope and control unit is so compact that all devices can be put on roll containers and transported to the point of operation by only one operator. Long transport routes of the highly sensitive biological samples, additional cooling systems and other equipment are thus no longer necessary.
The process from the extraction of the tissue or other biological sample to the decision about the microscopically gained results is much more efficient and less risky than with conventional methods which have to resort to complex, alignment sensitive and expensive OPO (optical parametric oscillating) systems which are bound to laser labs and thus immobile.
Copyright by Bettina Kristin Petrasch, WinWinTec CEO
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